University of Las Palmas de Gran Canaria – BIOPharma-IUIBS Group

In 2009, Molecular and Translational Pharmacology Group (BIOPharma Lab) at University of Las Palmas de Gran Canaria (ULPGC) started a Drug Discovery Project whose goal is to use Phenotypic-based Drug Discovery (PDD) in combination with Target-based Drug Discovery (TDD) strategies to find small molecules with biomedical application. These strategies apply Standard Work Procedures on cell-based assays directed at the discovery of pharmacologically active small-molecules and, ultimately, predicting their efficacy, ADMET, and mechanism of action (MAO). Since 2016, Molecular and Translational Pharmacology Group (BIOPharma Lab) is located at University Institute for Biomedical and Health Research (www.IUIBS.ulpgc.es) where it has built screening and preclinical research services. Therefore, internal (ULPGC) and external (R&D companies, Universities, institutes/centers) researchers can collaborate to find solutions in Research Projects within the area of Medical Chemistry  – particularly focused on diseases linked to molecular targets in metabolism-related diseases, blood cancer, ER+ and ER- breast cancer, or Inflamatory diseases -. Studies on drug reposition, drug resistance, and drug sinergism are also implemented in our Drug Discovery programs. Technically, BIOPharma Lab uses high-medium throughput assays that allows the efficient and dynamic 2D/3D phenotypes and transcriptome analysis on in vitro and ex vivo animal and human models. Chemical, Docking and Molecular dinamic models support original synthesis and further developoment of chemical libraries and identification of novel hits. Animal Facilities at IUIBS, and other collaborative centers, are frequently used to explore the efficacy, ADMET and toxicity in vivo. BIOPharma lab at IUIBS and our partner, the Organic Chemical Group (QUIBIONAT) – IUBO at University of La Laguna (www.ull.es/grupoinvestigacion/quibionat/) have created a solid experienced group of multidisciplinary scientists to develop collaborative research programs on Medicinal Chemistry and Preclinical Pharmacology in the Canary Islands to find therapeutic solutions to human diseases with a particular focus on STAT and ER-related diseases. Our group is composed by a multidisciplinary team of senior researchers, PostDoct researchers, PhD students, PTA, and, highly motivated undergraduates are also welcome.