Neurobioquimica

The Neurobiochemistry lab is a consolidated research group recognized by the University of Salamaca (GIR Neurobiochemistry) and the Junta de Castilla y León (UIC013). Our research group is interested in intercellular communication in the brain during health and disease. We are currently studying one of the deadliest brain tumors, glioblastoma, and its host brain microenvironment. Our basic research has been translated into the design of a connexin43 mimetic peptide (TAT-Cx43_266-283) with the ability to inhibit the activity of Src, an important oncoprotein involved in several signaling pathways related to cancer. Indeed, the work developed by our research group over the last few years, has demonstrated that TAT-Cx43_266-283 exerts potent anti-oncogenic effects in preclinical models of glioblastoma.  We are further investigating the effect of this molecule to advance in the proposal of a clinical trial in target-selected patients with glioblastoma.