Organization type
- Academic research institution
Optimization phases
- In vivo animal models (including assay/model development and testing)
Centro de Biomedicina Experimental (CEBEGA)
The “Centro de Biomedicina Experimental” (CEBEGA) is a great infrastructure devoted to animal research. CEBEGA is born oriented to provide service to all agents in Life Sciences, both in the Galician university system, health research institutes, as well in the business sector in the fields of biomedicine, biotechnology, and agri-food.
With a built area of 5,900 m2, located at the International Excellence Campus of the University of Santiago de Compostela (USC) (Galicia, Spain), CEBEGA has highly automated systems with the most advanced equipment, such as an automatic bottle washing system, an automatic rack washer, a cage washing tunnel, including robotic handling of dirty and clean cages and a complete management system for clean and dirty bedding, in a clear commitment to energy efficiency and ergonomics at work.
Some objectives of CEBEGA are: to satisfy the demand for quality laboratory animals, defined sanitary and genetically, to provide unique infrastructures for the performance of the most advanced biomedical experimentation techniques based on animal models, as well as to serve as a specialized training center in laboratory animal science. Some of the offered services are:
- Production and supply of rodents under SPF conditions (C57Bl / 6, Swiss, Sprague-Dwaley)
- Housing and maintenance of rodents (SPF and conventional), zebrafish and rabbits.
- Daily monitoring of environmental and sanitary conditions
- On-site veterinary supervision and assistance
- Supply and administration of veterinary drugs
- Management of imports and exports in accordance with FELASA guidelines
In addition to state-of-the-art facilities, CEBEGA has a highly qualified staff (with PhD, MSc or DVM among them) that can provide experimental services on demand in a flexible and personalized way:
- Breeding and housing of rodents (mice and rats) under SPF or conventional conditions
- Genetically-modified mice colony management service, including crosses, weaning, genotyping and registrations in databases.
- Technical assistance in sampling, administration of substances, surgeries, etc.
- Generation and analysis of experimental tumor models: hetero- and orthotopic models (lung, breast, ovary, brain, pancreas); patient-derived xenografts.
- Preclinical analysis of experimental therapies: toxicology & biodistribution.
- Metabolic phenotyping service: indirect calorimetry, body composition, GTT, ITT…
- Preclinical imaging service: microPET, micro CT, optical imaging.
- Experimental irradiation
CEBEGA also offers an extensive catalog of training activities, such as practical training workshops, supervised work to obtain the license, specific courses, continuing education activities, etc.
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Anxo Vidal
Scientific Director
cebega@usc.es cebega@usc.es
881815417 881815417
CEBEGA. Avenida do Mestre Mateo, 41, 15706 Santiago de Compostela, A Coruña, España
- Ownership
- Public
- Research Group / Unit / Center / Plataform / Department
- Centro de Biomedicina Experimental (CEBEGA) da Universidade de Santiago de Compostela
Additional info
Always under the best conditions of health, welfare, and environmental enrichment CEBEGA has areas for the housing of the following species:
- Rodents (rat and mouse) under conventional and SPF conditions. Current capacity: >20,000 mice; >2,500 rats.
- Zebrafish, around 200 tanks with more than 900L capacity.
- Rabbits, 3 racks with cages for 27 individually housed adult animals.
CEBEGA has also surgical rooms, support laboratories and procedure rooms to carry out different invasive and non-invasive techniques, always with the highest quality standards. The Center makes available to users:
- Small equipment and instruments for procedures (restrainers, surgical lamps, peristaltic pump…)
- Isoflurane anesthesia equipment
- Infusion cabinets
- Microinjectors and micromanipulators
- Portable echocardiograph
- Cell culture room
- Behavior laboratory (Rotarod, Turn Meter, Treadmill, Openfield, WaterMaze, Zero-Maze, Skinner boxes...)
- Isotope laboratory
- Biosafety laboratory NBS-2
CEBEGA has a series of equipment of singular scientific-technical value, available to users in various modalities of use, self-service or with technical assistance:
- IVIS Spectrum Optical Imaging System: High sensitivity in vivo 2D optical imaging for fluorescence and bioluminescence
- microPET/CT Albira Bruker: hybrid equipment that allows to perform metabolic PET and anatomical CT studies in vivo in small animals. Multimodal imaging equipment that allows to obtain fused functional and structural images.
- MicroCT SkyScan 1278 Bruker: it allows in vivo anatomical studies in small animals, with a spatial resolution of 50-75 µm. The low radiation allows multiple image captures in the same animal for longitudinal studies.
- Bruker Minispec LF110 Whole Body Composition Analyzer: Based on the TD-NMR modality, it provides an accurate method to measure fat, free body fluid and lean tissue on live rodents or in isolated organs and tissues.
- TSE Phenomaster indirect calorimetry system: Includes locomotive activity module and climate chamber. This equipment allows the repeated measurement at adjustable intervals of different parameters related to the physical and metabolic activity of rodents, including amount of food and drink ingested, movement, volume of exhaled CO2 and consumed O2, respiratory exchange rate. All without interference from human interaction and standardizing environmental conditions.
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