Celtarys Research develops and commercializes new chemical tools to spread the use of fluorescence-based methods in drug discovery. Our proprietary chemical conjugation technology allows us to develop in a competitive manner and short time customized fluorescent ligands with optimal pharmacological and photophysical properties for any druggable target.
We have initially applied our technology to develop versatile fluorescent GPCR ligands which we have externally validated in several HTS assays such as FRET, Fluorescence Polarization, High Content Screening or Flow Cytometry, avoiding the use of radioactivity.
What our technology achieves:
-Optimized for each target: potent (Ki<100 nM) and selective (>100 x)
-Fluorescence based, no radioactivity – improved performance of your HTS assays.
-LEGO like approach: possibility of incorporating different fluorophores with desired photo-physical properties.
-Cost reduction: >60%
-Available of the shelf ligands for selected targets and possibility of custom-made ligands for your target.
What we offer: We have a catalogue of >20 fluorescent ligands for different families of GPCRs, including adenosine, dopamine, serotonin, cannabinoid, muscarinic receptors and Glucagon-like peptide-1 receptor (GLP1R). We also offer custom synthesis of specific fluorescent ligands for any target with therapeutic potential. Our technology allows us to develop in a competitive way and in a short time (<4 months) customized fluorescent ligands with optimal pharmacological and photophysical properties.
